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KMID : 0043320080310121530
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Archives of Pharmacal Research
2008 Volume.31 No. 12 p.1530 ~ p.1533
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Two Novel A-seco-Rearranged Lanostane Triterpenoids From Abies Sachalinensis
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Sun Bo-Hang
Gao Hui-yuan
Kuroyanagi Masonori
Wu Li-jun
Huang Jian
Hou Bai-ling
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Abstract
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Further chemical study led to two new A-seco-rearranged lanostane triterpenoid derivatives (1-2) and one known compound Abiesanolide C (3) from the ethyl acetate (EtOAc) soluble fraction of the MeOH extract of Abies sachalinensis needles. The new compounds were identified as 3,4-seco-8- (14→13R)abeo-17,13-friedo-9β-lanosta-4(28), 7, 14, 24-tetraen-26,23-olide-23-hydroxy-3-oic acid and methyl-3,4-seco-8-(14→13R) abeo-17,13-friedo-9β-lanosta-4(28), 7, 14, 24-tetraen-26,23-olide-23- hydroxy-3-oate, respectively. Structural determination of these compounds were carried out by the spectral studies especially by the two digital (2D)-NMR and high-resolution (HR)-MS experiences.
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KEYWORD
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Abies sachalinensis, Rearranged lanostane, A-seco-lanostane
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